صيدليات الحسن تغيان

صيدليات الحسن عبد العزيزتغيان -ديروط اسيوط-

الثلاثاء، 15 مارس، 2011

Drug distribution


the process by which a drug reversibly leaves the blood stream and enters the interstitium (extracellular fluid) and/or the cells of tissues
Factors affect drug distribution
A- blood flow
B- capillary permeability which determined by
Capillary structure
ex : blood brain barrier : lipid soluble drugs readily penetrate to the CNS since they can dissolve in the membrane of its endothelial cells but ionized or polar drugs generally fail to enter the CNS

Drug structure
Binding of drugs to proteins
reversible binding to plasma proteins sequesters drugs in a non diffusible form and slows their transfer out of the vascular compartment

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